BMY vs LLY Stock Comparison: AI Score, Valuation, Performance and Upside
BMY (Bristol-Myers Squibb) and LLY (Eli Lilly) are both major pharmaceutical companies but at very different market positions — Bristol-Myers Squibb is managing Revlimid revenue decline while growing Opdivo and rebuilding its pipeline, while Eli Lilly is experiencing an extraordinary commercial ramp of its GLP-1/GIP obesity and diabetes drugs that have made it one of the most valuable companies globally. BMS is the value/recovery story; Lilly is the growth story of the pharmaceutical decade.
BMY vs LLY is oncology/immunology portfolio navigating LOE headwinds (Bristol-Myers Squibb's Opdivo checkpoint inhibitor franchise and diversified pipeline working to offset Revlimid's patent cliff with Eliquis as the cash flow anchor) versus GLP-1 obesity and diabetes drug revolution (Eli Lilly's Mounjaro/Zepbound tirzepatide creating the pharmaceutical decade's biggest commercial opportunity in the massive global obesity treatment market) — value/pipeline recovery versus growth at extraordinary scale.
LLY holds the edge across 3 of 5 key metrics in this comparison. LLY has delivered stronger 1-year price return (+38.84% vs +14.33%), though BMY trades at the lower forward P/E (9.27x vs 25.47x). LLY leads on both revenue growth (55.50%) and operating margin (49.39%), suggesting a stronger fundamental setup on both dimensions. Analyst consensus implies meaningfully more upside for BMY (+10.41%) than for LLY (+7.31%).
- →Want a value-oriented large-cap pharmaceutical with Opdivo's established oncology franchise and Eliquis cash flows providing earnings support while the pipeline works to offset Revlimid headwinds
- →Value BMS's dividend and capital return as a pharma income stock whose current price may reflect the Revlimid discount more than future pipeline value
- →Believe BMS's diversified oncology pipeline (CAR-T, tyrosine kinase inhibitors, new cancer indications) will generate sufficient revenue to stabilize earnings after the Revlimid LOE period
- →Want maximum exposure to the obesity and diabetes drug revolution — Lilly's Mounjaro/Zepbound franchise is the central holding for investors who believe GLP-1/GIP drugs represent a generational pharmaceutical opportunity
- →Value Lilly's best-in-class tirzepatide efficacy data as positioning it to capture premium market share in the massive obesity treatment market versus Novo Nordisk's competing products
- →Accept Lilly's very high valuation multiple as justified by the multi-decade market opportunity in obesity, which affects over 650 million adults globally, as the GLP-1 drug class expands into additional conditions
| Metric | BMY | LLY |
|---|---|---|
| AI score | 40.3 | 73.6 |
| AI rank | #1064 | #26 |
| Latest close | $54.00 | $1,098.57 |
| 1M return | -7.39% | +7.55% |
| 6M return | +0.84% | +5.45% |
| 1Y return | +14.33% | +38.84% |
How much would $10,000 be worth today if invested at the start of each period, with all dividends reinvested?
| Period | BMY | LLY |
|---|---|---|
| 1Y ago | $11.53K (+15.3%) started 2025-06-18 | $13.99K (+39.9%) started 2025-06-18 |
| 5Y ago | $11.08K (+10.8%) started 2021-06-21 | $53.49K (+434.9%) started 2021-06-21 |
| 10Y ago | $14.48K (+44.8%) started 2016-06-20 | $206.62K (+1966.2%) started 2016-06-20 |
Hypothetical — past performance does not guarantee future results.
| Metric | BMY | LLY |
|---|---|---|
| Market cap | $116.66B | $1.01T |
| Trailing P/E | 16.00 | 40.32 |
| Forward P/E | 9.27 | 25.47 |
| Price/Sales | 2.07 | 14.10 |
| EV/Revenue | 3.15 | 14.51 |
| Analyst target | $63.08 | $1,215.79 |
| Target upside | +10.41% | +7.31% |
| Metric | BMY | LLY |
|---|---|---|
| Revenue growth | 2.60% | 55.50% |
| Earnings growth | 9.20% | 169.90% |
| EPS growth | +9.20% | +169.90% |
| FCF margin | +20.32% | +12.67% |
| Operating margin | 33.04% | 49.39% |
| Profit margin | 15.01% | 34.99% |
| ROIC proxy | 38.73% | 107.46% |
| Return on equity | 38.73% | 107.46% |
| Dividend yield | 4.41% | 0.61% |
| Beta | 0.24 | 0.52 |
| Debt/equity | 230.97 | 139.01 |
| Current ratio | 1.42 | 1.50 |
| Quick ratio | 1.18 | 0.72 |
Lower drawdown and smaller single-period drops generally indicate a smoother ride, though they do not guarantee lower future risk.
| Period | Metric | BMY | LLY |
|---|---|---|---|
| 1Y | Growth | +15.29% | +39.94% |
| CAGR | +15.31% | +40.01% | |
| Sharpe ratio | 0.50 | 0.96 | |
| Max drawdown | 13.42% | 23.31% | |
| Max daily drop | 5.81% | 14.14% | |
| Max wkly drop | 11.50% | 17.93% | |
| 5Y | Growth | -5.92% | +413.56% |
| CAGR | -1.21% | +38.78% | |
| Sharpe ratio | -0.12 | 1.04 | |
| Max drawdown | 47.67% | 34.48% | |
| Max daily drop | 8.51% | 14.14% | |
| Max wkly drop | 11.78% | 17.93% | |
| 10Y | Growth | +2.48% | +1649.40% |
| CAGR | +0.25% | +33.16% | |
| Sharpe ratio | -0.04 | 0.95 | |
| Max drawdown | 47.67% | 34.48% | |
| Max daily drop | 15.99% | 14.14% | |
| Max wkly drop | 20.86% | 17.93% |
| Category | BMY | LLY |
|---|---|---|
| Company | Bristol-Myers Squibb Company | Eli Lilly and Company |
| Sector | Healthcare | Healthcare |
| Industry | Drug Manufacturers - General | Drug Manufacturers - General |
| Core business | Bristol-Myers Squibb (BMS) is a global biopharmaceutical company specializing in oncology, hematology, and immunology — with key products including Opdivo (nivolumab, PD-1 checkpoint inhibitor for multiple cancers), Revlimid (lenalidomide, multiple myeloma, now facing generic competition), Eliquis (apixaban, blood thinner with Pfizer), Yervoy (ipilimumab, melanoma), Camzyos (cardiac myosin inhibitor), and Reblozyl (beta-thalassemia). BMS made major acquisitions including Celgene (2019) and Turning Point Therapeutics. | Eli Lilly is a global pharmaceutical company with the most commercially successful weight loss and diabetes drug franchise in history — Mounjaro (tirzepatide, type 2 diabetes), Zepbound (tirzepatide, obesity), Trulicity (dulaglutide, type 2 diabetes), and Verzenio (abemaciclib, breast cancer). Lilly's GLP-1/GIP dual agonist tirzepatide (Mounjaro/Zepbound) achieved unprecedented weight loss results (22.5% body weight reduction in clinical trials) and is transforming the pharmaceutical industry's market capitalization. |
| Investor focus | Investors track BMS's revenue trajectory as Revlimid loses patent protection (significant revenue loss from generic competition), the growth of Opdivo and newer oncology assets (Breyanzi CAR-T, Krazati), pipeline development across oncology and cardiovascular, and cost management as BMS navigates revenue headwinds from Revlimid loss of exclusivity. | Investors track Lilly's Mounjaro and Zepbound quarterly revenue growth, manufacturing capacity expansion to meet the massive GLP-1 demand surge, incretin class competitive dynamics with Novo Nordisk's semaglutide (Ozempic/Wegovy), pipeline readouts for oral GLP-1 and next-generation obesity drugs, and Lilly's valuation premium relative to pharmaceutical peers. |
- →Opdivo checkpoint inhibitor franchise in multiple cancer indications — Opdivo has FDA approvals across 10+ cancer types (lung, kidney, bladder, melanoma, esophageal, gastric) and continues gaining new indications through ongoing clinical trials; the checkpoint inhibitor class remains a standard of care in oncology
- →Eliquis (with Pfizer) is a top-selling anticoagulant globally — Eliquis's revenue from the BMS/Pfizer partnership generates billions annually and has patent protection extending into the late 2020s, providing a durable cash flow stream
- →Diversified pipeline across oncology, cardiovascular, and immunology — BMS has multiple pipeline candidates that could generate meaningful revenue in the 2025-2030 timeframe to offset Revlimid headwinds
- →Mounjaro/Zepbound dual GIP/GLP-1 agonist with best-in-class weight loss efficacy — tirzepatide's superior weight loss outcomes (22.5%) versus semaglutide's (~15%) in head-to-head data positions Lilly favorably versus Novo Nordisk's Wegovy in the massive obesity treatment market
- →Obesity market structural tailwind is potentially the largest pharmaceutical opportunity in history — approximately 650 million obese adults globally; obesity's links to diabetes, heart disease, sleep apnea, and cancer make effective treatment a major public health priority; GLP-1/GIP drugs are being studied in many adjacent conditions
- →Manufacturing capacity expansion to capture structural demand — Lilly is investing $6+ billion in new manufacturing facilities to meet demand for injectable and oral incretin drugs; this capacity build positions Lilly for years of supply-constrained revenue growth
- →Revlimid LOE creates significant revenue headwind — Revlimid's loss of exclusivity (beginning 2022 in the U.S.) results in dramatic revenue decline as generic competition reduces market exclusivity; this headwind pressures BMS's total revenue for several years
- →Execution risk on pipeline to offset Revlimid — BMS needs multiple pipeline successes to replace Revlimid revenue; pipeline failures or competitive losses in key oncology indications would be materially negative
- →Opdivo competition from newer checkpoint inhibitors — Keytruda (Merck's pembrolizumab) has become the dominant PD-1 inhibitor in most cancers, gaining market share from Opdivo; BMS must differentiate Opdivo through specific combination regimens and biomarker-selected patient populations
- →Manufacturing capacity is the near-term constraint on revenue — demand for Mounjaro and Zepbound significantly exceeds Lilly's production capacity; inability to meet demand cedes market share to Novo Nordisk and delays peak revenue realization
- →Novo Nordisk semaglutide competition — Ozempic (diabetes) and Wegovy (obesity) remain the market leaders; Novo Nordisk's competitive response and pricing may limit Lilly's market share expansion
- →Oral GLP-1 race is critical for long-term market expansion — injectable GLP-1 drugs limit adoption among patients preferring oral medications; Lilly's oral GLP-1 (orforglipron) and Novo's oral semaglutide are competing for a potentially massive oral obesity treatment market
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